TYK145

An ultra-rapid metabolizer of the pro-drug codeine (metabolized to morphine) is at risk for which of the following:

a) Poor pain control due to reduced plasma concentrations of morphine

b) Apnea due to accumulation of active metabolites

c) Both A and B

d) None of the above

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Answer

Answer b.

Ultra-rapid metabolizers of codeine will have increased codeine clearance. This will result in increased formation and plasma concentrations of the active metabolite (morphine) placing these patients at risk of toxic effects including apnea.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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