TYK144
All of the following families of cytochrome P450 enzymes increase in activity over the first year of life EXCEPT:
a) CYP1A2
b) CYP2C9 and CYP2C19
c) CYP3A4 and CYP3A7
d) None of the above
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All of the following families of cytochrome P450 enzymes increase in activity over the first year of life EXCEPT:
a) CYP1A2
b) CYP2C9 and CYP2C19
c) CYP3A4 and CYP3A7
d) None of the above
Answer c.
The CYP3A family, which is responsible for the metabolism of approximately 40% of medications, shows developmental differences in expression.
CYP3A7 is highest at birth and activity decreases over the first year; CYP3A4 levels increase over the first year of life.