TYK143
Which of the following drug characteristics results in a smaller drug volume of distribution:
a) Nonpolar drugs
b) Lipophilic drugs
c) Small molecular size
d) None of the above
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Which of the following drug characteristics results in a smaller drug volume of distribution:
a) Nonpolar drugs
b) Lipophilic drugs
c) Small molecular size
d) None of the above
Answer d.
Lipophilic and nonpolar drugs as well as drugs of smaller molecular size tend to have increased (not decreased) volumes of distribution.