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Which of the following conditions increases pulmonary vascular resistance?
A. Hyperoxia
B. Alkalosis
C. Low hematocrit
D. Atelectasis
Answer
The answer is D. Atelectasis. Various physiologic conditions may affect pulmonary vascular resistance (PVR). Situations that may increase PVR include hypoxia, hypercarbia and/or acidosis, positive pressure ventilation (and PEEP above FRC), high hematocrit, atelectasis (or PEEP below FRC). Situations that decrease PVR include hyperoxia or oxygen supplementation, hypocarbia and/or alkalosis, PEEP at FRC, anemia and nitric oxide.
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