TYK189

The ductus arteriosus:

a) is functionally a right-to-left shunt during fetal life

b) may be closed artificially by administering intravenous prostaglandin E1

c) usually persists as a patent vascular structure throughout the neonatal period before it fibroses

d) may reopen in response to overzealous ventilation with an FiO2 >50%

e) responds with delayed closure to the administration of indomethacin

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Answer

Answer a.

Prostaglandin E1 is administered in order to keep the ductus arteriosus open; the ductus arteriosus typically closes in the first 12 hours of extra-uterine life; acidosis and hypoxemia may lead to reopening of the ductus arteriosus; indomethacin is a treatment option for closure of a persistently open ductus arteriosus.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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