TYK158

A theoretical drug is being studied for pharmacokinetic properties. It has a clearance of 10 L/min and an elimination constant of 0.2 min-1 . Which of the following is the best estimate for volume of distribution of this drug?

a) 2 liters

b) 20 liters

c) 50 liters

d) 100 liters

e) 50 mL

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Answer

Answer c.

Based on the formula Ke = CL / Vd, the Vd may be solved for as Vd = CL / Ke. Thus, the volume of distribution of this drug is CL / Ke = 10 L/min / 0.2 min-1 = 50 Liters. Note that it is very important to be consistent with units of measure (mL vs. L, min vs. hour) for these calculations.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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