TYK158
A theoretical drug is being studied for pharmacokinetic properties. It has a clearance of 10 L/min and an elimination constant of 0.2 min-1 . Which of the following is the best estimate for volume of distribution of this drug?
a) 2 liters
b) 20 liters
c) 50 liters
d) 100 liters
e) 50 mL
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Answer
Answer c.
Based on the formula Ke = CL / Vd, the Vd may be solved for as Vd = CL / Ke. Thus, the volume of distribution of this drug is CL / Ke = 10 L/min / 0.2 min-1 = 50 Liters. Note that it is very important to be consistent with units of measure (mL vs. L, min vs. hour) for these calculations.
Notes
- This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.
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