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TYK22: Difference between revisions
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Which of the following is NOT true concerning clonidine? | Which of the following is NOT true concerning clonidine? | ||
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D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE) | D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE) | ||
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==Answer== | ==Answer== | ||
The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated. | The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated. | ||
==Notes== | ==Notes== | ||
<references /> | <references /> | ||
:[[wikipedia:Clonidine]] | |||
==Keywords== | ==Keywords== | ||
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