3,688
edits
TYK22: Difference between revisions
Jump to navigation
Jump to search
no edit summary
m (1 revision imported) |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
Which of the following is NOT true concerning clonidine? | Which of the following is NOT true concerning clonidine? | ||
| Line 11: | Line 10: | ||
D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE) | D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE) | ||
<div class="mw-customtoggle-TYK_Answer" style="text-align: right; color:#0000ff">Click for Answer</div> | |||
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-TYK_Answer"> | |||
<div class="mw-collapsible- | |||
==Answer== | ==Answer== | ||
The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated. | The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated. | ||
==Notes== | ==Notes== | ||
<references /> | <references /> | ||
:[[wikipedia:Clonidine]] | |||
==Keywords== | ==Keywords== | ||
</div> | </div> | ||
---- | ---- | ||
---- | ---- | ||