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Which of the following is FALSE regarding mineralocorticoids?
a) Mineralocorticoids are primarily produced in the zona glomerulosa.
b) ACE-inhibitors promote the conversion of corticosterone to aldosterone.
c) Aldosterone increases sodium reabsorption in the renal principle cells of late distal tubule and collecting duct
d) Decreased renal perfusion pressure is a potent stimulant of aldosterone secretion.
e) Mineralocorticoid activity is regulated by a hormone produced in the kidney.
Answer
Answer b. Angiotensin II is responsible for the conversion of corticosterone to aldosterone in the zona glomerulosa; thus, ACE-inhibitors, which prevent conversion of Angiotensin I to Angiotensin II, will inhibit the production of aldosterone. The renin-angiotensin-aldosterone system is regulated by renin, a hormone released by the juxtaglomerular apparatus in the kidney in response to hyponatremia, hypotension, or adrenergic stimulation.
Notes
- This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.