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All of the following statements are true about immunosuppressive medications EXCEPT:

a) Corticosteriods are the mainstay of treatment for acute rejection, with calcineurin inhibitors used for steroid-resistant episodes

b) Interleukin-2 is a primarily T-cell produced cytokine that mediates graft rejection

c) Development of insulin-dependent diabetes after transplant is associated with tacrolimus

d) Cytokine release syndrome, characterized by hyperpyrexia, cardiovascular collapse, and pulmonary edema, is most closely associated with IL-2 inhibitors

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Answer

Answer d. Cytokine release syndrome is most commonly associated with antithymocyte and antilymphocyte antibodies, not IL-2 inhibitors.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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