Recognizing and Managing the Difficult Pediatric Airway
Introduction
Difficult pediatric airway consists of difficulty in face-mask ventilation, direct or indirect laryngoscopy, tracheal intubation, supraglottic airway device placement or front-of-neck airway. In summary, it is the impossibility to ensure adequate oxygenation after general anesthesia induction. As so, that is the priority while facing a difficult airway: to guarantee oxygenation!
Remember of the following particularities of pediatric patients before airway management, specially in the smaller ones (age < 2 yo):
- They have big heads: occiput is large relative to the rest of the body, leading to airway obstruction due to cervical spine flexion. Place shoulder roll to optimize airway alignment;
- They have large, omega-shaped epiglottis. Sometimes, it is necessary to pinch epiglottis during laryngoscopy to visualize vocal cords;
- They have high oxygen consumption and low functional residual capacity, causing faster desaturation during apnea periods;
- They are susceptible to gastric distension during face-mask ventilation. As the stomach increases its volume, the diaphragm is cephalically displaced, hampering face-mask ventilation. The harder it is tried to ventilate in this situation, more air is forced into the stomach and it becomes even harder to ventilate afterall, creating a vicious cycle. When a previously easy face-mask ventilation becomes harder after a long period of ventilation, ALWAYS remember of gastric distention. Place an orogastric tube to empty the stomach!
The main risk factors for difficult airway in pediatric patients are the following: genetic syndromes (specially the ones which present craniofacial anomalies); Micrognathia; Weight < 10 kg (small children); > 3 direct laryngoscopy attempts; > 2 tracheal intubation attempts. As you may see from this list, a very important principle in pediatric airway management is to limit intubation attempts, as further manipulation of children's airway increase the risk of complications.
Some principles must be followed in difficult pediatric airway management:
- Call for help;
- Communicate surgery team and prepare for the possibility of a surgical airway;
- Have a supraglottic airway device available to rescue airway in case of difficult face-mask ventilation;
- Provide passive oxygenation until airway is guaranteed. It is possible to use high-flow devices or low-flow devices, such as nasal or pharyngeal cannulas. In any case, always be aware of gastric distension. If using a low-flow device, limit the flow to 2 L/min to avoid this complication;
- Have advanced airway devices in the operating room, such as video laryngoscope and/or flexible fiberoptic bronchoscope;
- If possible, always maintain spontaneous ventilation.
General anesthesia induction under spontaneous ventilation
Many induction techniques can be used to maintain spontaneous ventilation, both inhalational or IV.
If using inhaled agents alone, such as sevoflurane, remember that MAC BAR is around 1.5 - 2 MAC and titrate the dose to adequate anesthetic plan for airway manipulation.
In the impossibility of inhalational induction, it is possible to use IV agents alone. Ketamine is a good choice, as it has analgesic properties and produces less respiratory depression than other hypnotic drugs. It is also described the use of propofol or low doses of midazolam + fentanyl for this purpose. If using ketamine or propofol, titrate incremental doses of 0,25-0,5 mg/kg until adequate anesthetic plan. A side effect of ketamine is sialorrhea, that may difficult airway visualization. In this case, the use of an antisialagogue agent, such as atropine or glycopyrrolate, may be necessary.
Another possibility is the combination of both IV and inhaled agents for anesthesia induction, such as sevoflurane and ketamine. In this case, a lesser dose from the two anesthetics is used, reducing adverse effects and providing a better anesthetic plan.
A way to test if the patient is in adequate anesthetic plan for airway manipulation is to perform a 5-second jaw-thrust. In the absence of movement, tachycardia and tachypnea, the patients is considered to be in a small risk of airway reaction during manipulation.
Difficult bag-mask ventilation
In the scenario of difficult ventilation, the following steps can be considered:
- place an oropharyngeal or nasopharyngeal device;
- correct positioning and technique: place shoulder roll, if indicated; use two hands, making chin lift and jaw thrust maneuvers; consider lateral decubitus to help opening upper airway;
- remember of laryngospasm. If present, use CPAP and deepen anesthetic plane. Consider muscular relaxant if refractory laryngospasm;
- remember of gastric distension. If present, empty stomach with an orogastric tube;
If none of the measures above work, place a supraglottic airway device (SAD). If adequate ventilation is obtained and the surgery can be safely conducted with the SAD, proceed. However if tracheal intubation is needed, use the SAD as a conduit to fiberoptic intubation. Nevertheless, if SAD fails to grant adequate ventilation, proceed to CICO scenario (cannot intubate, cannot oxygenate) or awake the patient if SpO2 permits (slow decline with stable hemodynamics). In CICO scenario, front-of-neck access must be made preferably by the surgery or ENT team. In the absence of them, anesthesiologist must perform a cricothyroidotomy by his/her preferable technique.
Easy bag-mask ventilation, difficult direct laryngoscopy
In this scenario, always remember to limit the attempts of laryngoscopy and intubation! Transition to indirect technique of laryngoscopy as soon as possible and use auxiliary devices as needed (e.g. bougie). If advanced techniques also fail, place a SAD and follow the steps described before.
Example of pediatric difficult airway algorithms
UK: Paediatric difficult airway guidelines - Difficult Airway Society
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Relevant Article Depot:
Pediatric Anesthesia: Special Issue:Pediatric Airway Special Issue
NEJM: Management of the Difficult Airway
The Congenital Difficult Airway in Pediatrics
Decision Making in the Difficult Airway Algorithm
Error traps in pediatric difficult airway management
OA-SPA Virtual Grand Rounds / Management of the Difficult Pediatric Airway
10 Rules for Approaching Difficult Intubation: Always Prepare for Failure
Difficult Airway Management in Neonates: Fiberoptic Intubation via Laryngeal Mask Airway
Prediction of Difficult Laryngoscopy Using Ultrasound: A Systematic Review and Meta-Analysis
Preventing difficult facemask ventilation in children: all is well that starts well
Airway triage: a novel application-based method for airway assessment and risk stratification
Pediatric upper airway and congenital anomalies
Fiadjoe JE, Nishisaki A, Jagannathan N, Hunyady AI, Greenberg RS, Reynolds PI, Matuszczak ME, Rehman MA, Polaner DM, Szmuk P, Nadkarni VM, McGowan FX, Jr., Litman RS, Kovatsis PG: Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (PeDI) registry: a prospective cohort analysis. Lancet Respir Med 2016; 4: 37–48
Engelhardt T, Fiadjoe JE, Weiss M, Baker P, Bew S, Echeverry Marín P, von Ungern-Sternberg BS: A framework for the management of the pediatric airway. Paediatr Anaesth 2019; 29: 985–992
Garcia-Marcinkiewicz AG, Kovatsis PG, Hunyady AI, Olomu PN, Zhang B, Sathyamoorthy M, Gonzalez A, Kanmanthreddy S, Gálvez JA, Franz AM, Peyton J, Park R, Kiss EE, Sommerfield D, Griffis H, Nishisaki A, von Ungern-Sternberg BS, Nadkarni VM, McGowan FX, Jr., Fiadjoe JE: First-attempt success rate of video laryngoscopy in small infants (VISI): a multicentre, randomised controlled trial. Lancet 2020; 396: 1905–1913
Disma N, Asai T, Cools E, Cronin A, Engelhardt T, Fiadjoe J, Fuchs A, Garcia-Marcinkiewicz A, Habre W, Heath C, Johansen M, Kaufmann J, Kleine-Brueggeney M, Kovatsis PG, Kranke P, Lusardi AC, Matava C, Peyton J, Riva T, Romero CS, von Ungern-Sternberg B, Veyckemans F, Afshari A: Airway management in neonates and infants: European Society of Anaesthesiology and Intensive Care and British Journal of Anaesthesia joint guidelines. Eur J Anaesthesiol 2024; 41: 3–23
Sequera-Ramos L, Laverriere EK, Garcia-Marcinkiewicz AG, Zhang B, Kovatsis PG, Fiadjoe JE: Sedation versus General Anesthesia for Tracheal Intubation in Children with Difficult Airways: A Cohort Study from the Pediatric Difficult Intubation Registry. Anesthesiology 2022; 137: 418–433
Burjek NE, Nishisaki A, Fiadjoe JE, Adams HD, Peeples KN, Raman VT, Olomu PN, Kovatsis PG, Jagannathan N, Hunyady A, Bosenberg A, Tham S, Low D, Hopkins P, Glover C, Olutoye O, Szmuk P, McCloskey J, Dalesio N, Koka R, Greenberg R, Watkins S, Patel V, Reynolds P, Matuszczak M, Jain R, Khalil S, Polaner D, Zieg J, Szolnoki J, Sathyamoorthy K, Taicher B, Riveros Perez NR, Bhattacharya S, Bhalla T, Stricker P, Lockman J, Galvez J, Rehman M, Von Ungern-Sternberg B, Sommerfield D, Soneru C, Chiao F, Richtsfeld M, Belani K, Sarmiento L, Mireles S, Bilen Rosas G, Park R, Peyton J: Videolaryngoscopy versus Fiber-optic Intubation through a Supraglottic Airway in Children with a Difficult Airway: An Analysis from the Multicenter Pediatric Difficult Intubation Registry. Anesthesiology 2017; 127: 432–440
Stein ML, Nagle JH, Templeton TW, Staffa SJ, Flynn SG, Bordini M, Nykiel-Bailey S, Garcia-Marcinkiewicz AG, Padiyath F, Matuszczak M, Lee AC, Peyton JM, Park RS, von Ungern-Sternberg BS, Olomu PN, Hunyady AI, Matava C, Fiadjoe JE, Kovatsis PG: Comparing videolaryngoscopy and flexible bronchoscopy to rescue failed direct laryngoscopy in children: a propensity score matched analysis of the Pediatric Difficult Intubation Registry. Anaesthesia 2025; 80: 625–635
Evans MA, Caruso TJ: Rescuing failed direct laryngoscopy in children: one size does not fit all. Anaesthesia 2025; 80: 621–624