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Outside the neonatal period, SA has been used for general surgery (rectal biopsy, incision of rectal abscess), urological surgery (orchidopexy, circumcision), lower limb orthopaedic surgery,<ref>Dalens B, Veyckemans F. Traité d’Anesthésie Loco-Régionale, de la naissance à l’âge adulte. Montpellier: Sauramps Médical 2008, 463-512.</ref><sup>,</sup> and may be of particular use in developing countries as an alternative to general anaesthesia. | Outside the neonatal period, SA has been used for general surgery (rectal biopsy, incision of rectal abscess), urological surgery (orchidopexy, circumcision), lower limb orthopaedic surgery,<ref>Dalens B, Veyckemans F. Traité d’Anesthésie Loco-Régionale, de la naissance à l’âge adulte. Montpellier: Sauramps Médical 2008, 463-512.</ref><sup>,</sup> and may be of particular use in developing countries as an alternative to general anaesthesia. | ||
SA has also been suggested for patients in whom GA may pose a significant risk such as those with facial dysmorphia and difficult intubation, muscular dystrophy, family history of malignant hyperthermia or a full stomach with aspiration risk.<ref | SA has also been suggested for patients in whom GA may pose a significant risk such as those with facial dysmorphia and difficult intubation, muscular dystrophy, family history of malignant hyperthermia or a full stomach with aspiration risk.<ref name=":5" /> | ||
SA has also been described in combination with GA in children undergoing complex surgery. For instance, preoperative morphine SA combined with GA for scoliosis surgery is associated with reduced blood loss and better pain control.6,7 SA has been used with GA during cardiopulmonary bypass in neonates to blunt the stress response, protect hemodynamic status and reduce perioperative morbidity and mortality,4,9 although its use in this situation is not common. SA has also been described for use in chronic pain management.4,8 | SA has also been described in combination with GA in children undergoing complex surgery. For instance, preoperative morphine SA combined with GA for scoliosis surgery is associated with reduced blood loss and better pain control.6,7 SA has been used with GA during cardiopulmonary bypass in neonates to blunt the stress response, protect hemodynamic status and reduce perioperative morbidity and mortality,4,9 although its use in this situation is not common. SA has also been described for use in chronic pain management.4,8 | ||