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What is the most significant risk factor for cardiotoxicity from doxorubicin?

a) Dose of Doxorubicin

b) Duration of therapy

c) Family history

d) Patient age

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Answer

Answer a. Anthracycline cardiotoxicity is a lifetime cumulative dose-related side effect. Total lifetime dose should be monitored. In addition, serial echocardiography is important to monitor for cardiotoxicity, which may occur years following therapy.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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