Opiates

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Relevant Article Depot:

Morphine pharmacokinetics in early infancy

Demystifying Perioperative Methadone Administration in Children

Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children

Perioperative Opioid Administration: A Critical Review of Opioid-free versus Opioid-sparing Approaches

Evan D Kharasch, J David Clark, Jerome M Adams. Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management. Anesthesiology. 2022 Jan 1;136(1):10-30. PMID: 34874401

The Dose Response of Fentanyl in Neonatal Anesthesia

Buprenorphine Recommendations Enlist Anesthesiologists to Combat Opioid Abuse

Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist

Bringing Back the Balance: Opioid Reduction in Anesthesia

Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl

Boisvert-Plante V, Poulin-Harnois C, Ingelmo P, Einhorn LM. What we know and what we don't know about the perioperative use of methadone in children and adolescents. Paediatr Anaesth. 2023 Mar;33(3):185-192. PMID: 36281540.

1. Berde CB, Beyer JE, Bournaki MC, Levin CR, Sethna NF. Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children. J Pediatr. 1991 Jul;119(1 Pt 1):136-41. PMID: 2066846

2. Sharma A, Tallchief D, Blood J, Kim T, London A, Kharasch ED. Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology. 2011 Dec;115(6):1153-61. doi: 10.1097/ALN.0b013e318238fec5. PMID: 22037641; PMCID: PMC3560937.

3. Sadhasivam S, Aruldhas BW, Packiasabapathy S, Overholser BR, Zhang P, Zang Y, Renschler JS, Fitzgerald RE, Quinney SK. A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. Anesth Analg. 2021 Aug 1;133(2):327-337. doi: 10.1213/ANE.0000000000005366. PMID: 33481403; PMCID: PMC8282724.

4. Mok V, Sweetman S, Hernandez B, Casias T, Hylton J, Krause BM, Noonan KJ, Walker BJ. Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: A single center retrospective case series. Paediatr Anaesth. 2022 Oct;32(10):1159-1165. doi: 10.1111/pan.14526. Epub 2022 Jul 20. PMID: 35816392.