Local Anesthetic Systemic Toxicity - LAST

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Relevant Article Depot:

Local anesthetic systemic toxicity in children: a review of recent case reports and current literature - an infographic

Update on Local Anesthetic Toxicity, Prevention and Treatment During Regional Anesthesia in Infants and Children

Multiple myeloma and malignant lesions: a potential risk factor for local anesthetic systemic toxicity

https://twitter.com/jeffgadsden/status/1449446835911802880?s=21

Local anesthetic systemic toxicity in children: a review of recent case reports and current literature

and hemodynamic changes associated with unintentional intravascular injection of bupivacaine with epinephrine in infants

Updates in our understanding of local anaesthetic systemic toxicity: a narrative review

Local anesthetic systemic toxicity: current perspectives

The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017

Local Anesthetic Systemic Toxicity: A Review of Recent Case Reports and Registries

Local anesthetic systemic toxicity in children: a review of recent case reports and current literature

Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model

Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats

Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade

Local anesthetic systemic toxicity: Continuing Professional Development

Systematic review of the systemic concentrations of local anaesthetic after transversus abdominis plane block and rectus sheath block

The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety

Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion

LAST (Local Anesthetic Systemic Toxicity): A practical update for clinicians (Youtube)

Ramesh AS, Boretsky K. Local anesthetic systemic toxicity in children: a review of recent case reports and current literature. Reg Anesth Pain Med 2021;46: 909-914. doi: 10.1136/rapm-2021-102529. PMID: 34099573

Infographic

Gupta RK, Schwenk ES. Local anesthetic systemic toxicity in children: a review of recent case reports and current literature – an infographic. Reg Anesth Pain Med 2021;46: 915. doi: 10.1136/rapm-2021-102993. PMID: 34230193

Pharmacokinetics of local anaesthetics in infants and children

Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology