Opiates

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Relevant Article Depot:

General

Perioperative Opioid Administration: A Critical Review of Opioid-free versus Opioid-sparing Approaches

Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management

Bringing Back the Balance: Opioid Reduction in Anesthesia

Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl

Comparison of Fentanyl, Remifentanil, Sufentanil and Alfentanil in Combination with Propofol for General Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Intrathecal opioids for the management of post-operative pain

Bolus Dose Administration of Fentanyl in Obese Children: Do Settle for Less

Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review

Allergy

Clinical Manifestations and Diagnostic Evaluation of Opioid Allergy Labels - A Review

Opioid Hypersensitivity: Predictors of Allergy and Role of Drug Provocation Testing

Assessment of Opioid Cross-reactivity and Provider Perceptions in Hospitalized Patients With Reported Opioid Allergies

Morphine

Morphine pharmacokinetics in early infancy

Hydromorphone versus morphine: a historical cohort study to evaluate the quality of postoperative analgesia

Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers

Intrathecal Morphine Versus Extended-Release Epidural Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion

The Influence of Pharmacogenetic Factors on the Pharmacokinetics of Morphine and Its Metabolites in Pediatric Patients: A Systematic Review

Methadone

The pharmacokinetics of methadone and its metabolites in neonates, infants, and children

The Effects of Intraoperative Methadone on Postoperative Pain Control in Pediatric Patients: A Scoping Review

Demystifying Perioperative Methadone Administration in Children

What we know and what we don't know about the perioperative use of methadone in children and adolescents

Intraoperative methadone: Rediscovery, reappraisal, and reinvigoration?

Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children

Perioperative pharmacokinetics of methadone in adolescents

Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects

Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: A single center retrospective case series

The Effects of Intraoperative Methadone on Postoperative Pain Control in Pediatric Patients: A Scoping Review

Pro-Con Debate: Role of Methadone in Enhanced Recovery After Surgery Protocols—Superior Analgesic or Harmful Drug? Editorial

Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study

Podcast: Episode 262: Perioperative Methadone with Evan Kharash

Perioperative Methadone: The Practical, Opioid-Sparing Opioid” 1/4/24 Grand Rounds by: Evan Kharasch, M.D., Ph.D.

We Need to Talk About Methadone: Adding Discussions With Patients to Our Care Pathways

Methadone and a Clinical Pathway in Adolescent Idiopathic Scoliosis Surgery: A Historically Controlled Study

Murphy GS, Szokol JW. Intraoperative methadone in surgical patients: a review of clinical investigations. Anesthesiology. 2019 Sep; 131(3): 678-692. PMID: 31094758

Sharma A, Tallchief D, Blood J, Kim T, London A, Kharasch ED. Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology. 2011 Dec; 115(6): 1153-1161. PMID: 22037641

Hydromorphone

Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers

Fentanyl

Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children

The Dose Response of Fentanyl in Neonatal Anesthesia

The anomalous pharmacology of fentanyl

Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs

Analgesia and anesthesia in neonates

The fentanyl story

The anomalous pharmacology of fentanyl

Fentanyl Drives Startling Increases in Adolescent Overdose Deaths

Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review

Statpearls: Fentanyl

Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children

Intraoperative Methadone and Postoperative Anesthesia Care Unit Outcomes: A Retrospective Cohort Analysis

Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial

Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children

Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic–Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression

Buprenorphine

Buprenorphine Recommendations Enlist Anesthesiologists to Combat Opioid Abuse

Perioperative Management of Patients on Buprenorphine: A Literature Review

Naloxone

Naloxone hydrochloride: a review

Meperidine

Effects of meperidine on the newborn infant

OpenAnesthesia: Meperidine

Remifentanil

Hoshijima H, Takeuchi R, Kuratani N, et al. Incidence of postoperative shivering comparing remifentanil with other opioids: a meta-analysis. J Clin Anesth. 2016 Aug; 32: 300-12. PMID: 26432635

Nakasuji M, Nakamura M, Imanaka N, Tanaka M, Nomura M, Suh SH. Intraoperative high-dose remifentanil increases post-anaesthetic shivering. Br J Anaesth. 2010 Aug; 105(2): 162-7. PMID: 20542888

Komatsu R, Turan AM, Orhan-Sungur M, McGuire J, Radke OC, Apfel CC. Remifentanil for general anaesthesia: a systematic review. Anaesthesia. 2007 Dec; 62(12): 1266-80. PMID: 17991265

The effects of the administration sequence and the type of hypnotics on the development of remifentanil-induced chest wall rigidity: a randomized controlled trial

Tolerance

Hayhurst CJ, Durieux ME. Differential opioid tolerance and opioid-induced hyperalgesia: a clinical reality. Anesthesiology. 2016 Feb; 124(2): 483-488. PMID: 26594912

Dumas EO, Pollack GM. Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective. AAPS J. 2008 Dec; 10(4): 537-551. PMID: 18989788

Monitoring

Opioid-Induced Respiratory Depression—Pediatric Considerations

No patient shall be harmed by opioid-induced respiratory depression

Opioid Withdrawal Syndrome/Management

Recognition and Management of Iatrogenically Induced Opioid Dependence and Withdrawal in Children: Clinical Report

Recognition and management of iatrogenically induced opioid dependence and withdrawal in children

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility

Benzodiazepines and Development of Delirium in Critically Ill Children: Estimating the Causal Effect

Delirium in a Tertiary PICU: Risk Factors and Outcomes

Ista E, van Dijk M, Gamel C, Tibboel D, de Hoog M: Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: a first evaluation. Critical care medicine 2008, 36(8):2427–2432.

Ista E, de Hoog M, Tibboel D, Duivenvoorden HJ, van Dijk M: Psychometric Evaluation of the Sophia Observation Withdrawal Symptoms Scale in Critically Ill Children. Pediatric Critical Care Medicine 2013, 14(8):761–769.

Franck LS, Harris SK, Soetenga DJ, Amling JK, Curley MA: The Withdrawal Assessment Tool-1 (WAT-1): an assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients. PediatrCrit Care Med 2008, 9(6):573–580.

The “opioid crisis”

Larach DB, Hah JM, Brummett CM. Perioperative opioids, the opioid crisis, and the anesthesiologist. Anesthesiology. 2022 Apr; 136(4): 594-608. PMID: 35108351

Kharasch ED, Avram MJ, Clark JD. Rational perioperative opioid management in the era of the opioid crisis. Anesthesiology. 2020 Apr; 132(4): 603-605. PMID: 32058348

Scholzen E, Zeng AM, Schroeder KM. Perioperative management and analgesia for patients taking buprenorphine and other forms of medication-assisted treatment for substance abuse disorders. Adv Anesth. 2019 Dec; 37: 65-86. PMID: 31677660

Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist

An obituary for postoperative use of modified-release opioids

CDC - National Center for Health Statistics: U.S. Overdose Deaths Decrease Almost 27% in 2024

Association of Opioid Disposal Practices with Parental Education and a Home Opioid Disposal Kit Following Pediatric Ambulatory Surgery