Jump to content

Neuromuscular Blockade: Difference between revisions

From PedsAnesthesiaNet
No edit summary
No edit summary
Line 6: Line 6:
<b>Standards/Guidelines</b>
<b>Standards/Guidelines</b>


[https://pubmed.ncbi.nlm.nih.gov/36520073/ 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology 2023;138:13-41]
[https://pubmed.ncbi.nlm.nih.gov/36520073/ 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade]


[https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children]
[https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children]


[https://pubmed.ncbi.nlm.nih.gov/30594097/ Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study]
[https://pubmed.ncbi.nlm.nih.gov/30594097/ Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study]
[https://pubmed.ncbi.nlm.nih.gov/36377554/ Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care]




Line 22: Line 25:


[https://link.springer.com/article/10.2165/00003088-200443020-00001 Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance]
[https://link.springer.com/article/10.2165/00003088-200443020-00001 Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance]




Line 32: Line 36:


[https://pubmed.ncbi.nlm.nih.gov/28795964/ Neuromuscular Monitoring in the Perioperative Period]
[https://pubmed.ncbi.nlm.nih.gov/28795964/ Neuromuscular Monitoring in the Perioperative Period]
[https://pubmed.ncbi.nlm.nih.gov/6990835/ Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants]


[https://pubmed.ncbi.nlm.nih.gov/31607388/ Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data]
[https://pubmed.ncbi.nlm.nih.gov/31607388/ Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data]
Line 43: Line 49:
[https://pubs.asahq.org/anesthesiology/article/141/2/262/141383/Accuracy-and-Precision-of-Three-Acceleromyographs Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs]
[https://pubs.asahq.org/anesthesiology/article/141/2/262/141383/Accuracy-and-Precision-of-Three-Acceleromyographs Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs]


 
[https://journals.lww.com/anesthesiology/fulltext/2025/08000/skin_injury_after_removal_of_electrode_used_for.26.aspx Skin Injury after Removal of Electrode Used for Quantitative Monitoring of Neuromuscular Transmission]


<b>Agents</b>
<b>Agents</b>
Line 53: Line 59:


[https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia]
[https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia]
[https://pubmed.ncbi.nlm.nih.gov/3946815/ Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele]
   
   


Line 65: Line 74:


[https://pubs.asahq.org/anesthesiology/article/139/1/A16/138250/Goldilocks-and-the-Three-Rocuronium-Reversals-A Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study]
[https://pubs.asahq.org/anesthesiology/article/139/1/A16/138250/Goldilocks-and-the-Three-Rocuronium-Reversals-A Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study]
[https://pubmed.ncbi.nlm.nih.gov/12378667/ Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children]
[https://pubmed.ncbi.nlm.nih.gov/10485771/ Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action]


[[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium
[[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium
Line 87: Line 100:


Sugammadex
Sugammadex
[https://www.statpearls.com/ArticleLibrary/viewarticle/29661 StatPearls: Sugammadex]


[https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children]
[https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children]
Line 101: Line 116:


[https://www.bjaopen.org/article/S2772-6096(22)00091-0/fulltext Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study]
[https://www.bjaopen.org/article/S2772-6096(22)00091-0/fulltext Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study]
[https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15902 A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception]


[https://pubmed.ncbi.nlm.nih.gov/33329823/ Advantages and pitfalls of clinical application of sugammadex]
[https://pubmed.ncbi.nlm.nih.gov/33329823/ Advantages and pitfalls of clinical application of sugammadex]
Line 118: Line 131:
[https://www.bjanaesthesia.org/article/S0007-0912(23)00548-2/fulltext Recurarisation after sugammadex in children: review of case reports and recommendations]
[https://www.bjanaesthesia.org/article/S0007-0912(23)00548-2/fulltext Recurarisation after sugammadex in children: review of case reports and recommendations]


[https://journals.lww.com/anesthesia-analgesia/fulltext/2025/01000/factors_associated_with_decision_to_use_and_dosing.14.aspx Factors Associated With Decision to Use and Dosing of Sugammadex in Children: A Retrospective Cross-Sectional Observational Study]


Neostigmine
[https://pubmed.ncbi.nlm.nih.gov/39058621/ Impact of Sugammadex Introduction on Using Neuromuscular Blockade and Endotracheal Intubation in a Pediatric Hospital: A Retrospective, Observational Cross-Sectional Study]


[https://x.com/apsforg/status/1898792243835883675?s=46&t=X_9iaGrsYZbY5PJKh6nAPQ X tweet about sugammadex]


[https://pubmed.ncbi.nlm.nih.gov/39976619/ Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?]


'''Anaphylaxis'''
[https://pubmed.ncbi.nlm.nih.gov/31980926/ Heart rate changes following the administration of sugammadex in children: a prospective, observational study]


[https://pubmed.ncbi.nlm.nih.gov/26646837/ Sugammadex and rocuronium-induced anaphylaxis]
[https://journals.lww.com/anesthesiology/abstract/9900/sugammadex_for_reversal_of_neuromuscular_blockade.682.aspx Sugammadex for reversal of neuromuscular blockade in neonates and infants <2 years old: results from a phase IV randomized clinical trial]


[https://pubmed.ncbi.nlm.nih.gov/21149287/ Sugammadex in the management of rocuronium-induced anaphylaxis]
[https://pubmed.ncbi.nlm.nih.gov/32324657/ Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations]


[https://pubmed.ncbi.nlm.nih.gov/35212434/ Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports]
[https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective analysis of the safety and efficacy of sugammadex versus neostigmine for the reversal of neuromuscular blockade in children]


[https://pubmed.ncbi.nlm.nih.gov/22512555/ The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?]
[https://pubmed.ncbi.nlm.nih.gov/27859917/ Current evidence for the use of sugammadex in children]


[https://www.bjanaesthesia.org/article/S0007-0912(23)00104-6/fulltext Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study]
[https://pubmed.ncbi.nlm.nih.gov/37792601/ Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age]


[https://pubmed.ncbi.nlm.nih.gov/37279102/ Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal]


<b>Historic</b>
[https://pubmed.ncbi.nlm.nih.gov/37027807/ A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis]


Gallamine


Sugammadexand Women, Hormonal Regulation, and Contraceptives,


Micacurium
[https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15902 A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception]


[https://pubmed.ncbi.nlm.nih.gov/10638896/ Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury]
[https://anesth-pain-med.org/m/journal/view.php?doi=10.17085/apm.23041 What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives]


[https://www.apsf.org/article/safety-of-sugammadex-in-pregnancy-pediatrics-and-renal-failure/ Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure]


Curare




Neostigmine


[https://pubmed.ncbi.nlm.nih.gov/10485771/ https://pubmed.ncbi.nlm.nih.gov/10485771/]
[https://journals.lww.com/anesthesia-analgesia/fulltext/2025/05000/rocuronium_sugammadex_versus.1.aspx Rocuronium-Sugammadex Versus Cisatracurium-Neostigmine in Kidney Disease: Making Sense of Surprising Results]


[https://pubmed.ncbi.nlm.nih.gov/37171989/ Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring]


'''Anaphylaxis'''


[https://pubmed.ncbi.nlm.nih.gov/26646837/ Sugammadex and rocuronium-induced anaphylaxis]


Suárez Delgado JM, Hernández Soto R, Vilches Martín MJ, Romero RR, Vaz Calderón MA, García Perla JL. Anaesthetic considerations for myelomeningocele in neonates. Paediatr Anaesth. 1998; 8(4): 363-4. PMID: 9672939
[https://pubmed.ncbi.nlm.nih.gov/21149287/ Sugammadex in the management of rocuronium-induced anaphylaxis]


Dierdorf SF, McNiece WL, Rao CC, Wolfe TM, Means LJ. Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele. Anesthesiology. 1986 Feb; 64(2): 272-3. PMID: 3946815
[https://pubmed.ncbi.nlm.nih.gov/35212434/ Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports]


[https://pubmed.ncbi.nlm.nih.gov/22512555/ The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?]


 
[https://www.bjanaesthesia.org/article/S0007-0912(23)00104-6/fulltext Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study]
 
Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age. Paediatr Anaesth. 2023 Oct 4. doi: 10.1111/pan.14773. Epub ahead of print. PMID: 37792601
 
 
 
 
Thilen SR, Sherpa JR, James AM, Cain KC, Treggiari MM, Bhananker SM. Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring. Anesth Analg. 2024 Sep 1;139(3):536-544. doi: 10.1213/ANE.0000000000006511. Epub 2023 May 12. PMID: 37171989.
 
Mason LJ, Betts EK. Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants. Anesthesiology. 1980 May;52(5):441-2. doi: 10.1097/00000542-198005000-00015. PMID: 6990835.
 


[https://www.bjanaesthesia.org/article/S0007-0912(24)00560-9/fulltext Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort]
[https://www.bjanaesthesia.org/article/S0007-0912(24)00560-9/fulltext Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort]
[https://journals.lww.com/anesthesia-analgesia/fulltext/2025/01000/factors_associated_with_decision_to_use_and_dosing.14.aspx Factors Associated With Decision to Use and Dosing of Sugammadex in Children: A Retrospective Cross-Sectional Observational Study]
[https://anesth-pain-med.org/m/journal/view.php?doi=10.17085/apm.23041 What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives]
[https://www.statpearls.com/ArticleLibrary/viewarticle/29661 StatPearls: Sugammadex]


[https://www.bjanaesthesia.org/article/S0007-0912(24)00716-5/fulltext Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity]
[https://www.bjanaesthesia.org/article/S0007-0912(24)00716-5/fulltext Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity]


[https://pubmed.ncbi.nlm.nih.gov/12378667/ Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children]
[https://www.bjanaesthesia.org/article/S0007-0912(25)00284-3/fulltext Incidence of immediate hypersensitivity to sugammadex in Aotearoa New Zealand: a retrospective cohort study]


[https://x.com/apsforg/status/1898792243835883675?s=46&t=X_9iaGrsYZbY5PJKh6nAPQ X tweet about sugammadex]


[https://www.apsf.org/article/safety-of-sugammadex-in-pregnancy-pediatrics-and-renal-failure/ Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure]


[https://pubmed.ncbi.nlm.nih.gov/39058621/ Impact of Sugammadex Introduction on Using Neuromuscular Blockade and Endotracheal Intubation in a Pediatric Hospital: A Retrospective, Observational Cross-Sectional Study]
<b>Historic</b>


[https://pubmed.ncbi.nlm.nih.gov/39976619/ Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?]
Gallamine


[https://pubmed.ncbi.nlm.nih.gov/33543867/ A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade]


[https://pubmed.ncbi.nlm.nih.gov/36520073/ 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade]
Micacurium


[https://pubmed.ncbi.nlm.nih.gov/26418126/ Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium]
[https://pubmed.ncbi.nlm.nih.gov/10638896/ Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury]


[https://pubmed.ncbi.nlm.nih.gov/31980926/ Heart rate changes following the administration of sugammadex in children: a prospective, observational study]


[https://journals.lww.com/anesthesia-analgesia/fulltext/2025/05000/rocuronium_sugammadex_versus.1.aspx Rocuronium-Sugammadex Versus Cisatracurium-Neostigmine in Kidney Disease: Making Sense of Surprising Results]
Curare
 
[https://journals.lww.com/anesthesiology/abstract/9900/sugammadex_for_reversal_of_neuromuscular_blockade.682.aspx Sugammadex for reversal of neuromuscular blockade in neonates and infants <2 years old: results from a phase IV randomized clinical trial]
 
[Grigg E. Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations. Curr Opin Anaesthesiol. 2020 Jun; 33(3): 374-380. PMID: 32324657
 
Gaver RS, Brenn BR, Gartley A, Donahue BS. Retrospective analysis of the safety and efficacy of sugammadex versus neostigmine for the reversal of neuromuscular blockade in children. Anesth Analg. 2019 Oct; 129(4): 1124-1129. PMID: 31584918
 
Tobias JD. Current evidence for the use of sugammadex in children. Paediatr Anaesth. 2017 Feb; 27(2): 118-125. PMID: 27859917
 
[https://pmc.ncbi.nlm.nih.gov/articles/PMC12227211/ Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial]
 
[https://journals.lww.com/anesthesiology/fulltext/2025/08000/sugammadex_for_reversal_of_neuromuscular_blockade.17.aspx Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial]
 
[https://journals.lww.com/anesthesiology/fulltext/2025/08000/skin_injury_after_removal_of_electrode_used_for.26.aspx Skin Injury after Removal of Electrode Used for Quantitative Monitoring of Neuromuscular Transmission]
 
[https://www.bjanaesthesia.org/article/S0007-0912(25)00284-3/fulltext Incidence of immediate hypersensitivity to sugammadex in Aotearoa New Zealand: a retrospective cohort study]
 
Todd MM, Kopman AF: Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal. Anesthesiology 2023, 139(1):1–3.
 
Thilen SR, Weigel WA, Todd MM, Dutton RP, Lien CA, Grant SA, Szokol JW, Eriksson LI, Yaster M, Grant MD et al: 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology 2023, 138(1):13–41.
 
Fuchs-Buder T, Romero CS, Lewald H, Lamperti M, Afshari A, Hristovska AM, Schmartz D, Hinkelbein J, Longrois D, Popp M et al: Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care. European journal of anaesthesiology 2023, 40(2):82–94.
 
Bowdle TA, Haththotuwegama KJ, Jelacic S, Nguyen ST, Togashi K, Michaelsen KE: A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis. Anesthesiology 2023, 139(1):6–15.

Revision as of 22:52, 25 September 2025

This is a Stub Notice. This page has not been completed. You can work on this page by signing in and going to the Edit tab. Thanks for helping to make PedsAnesthesia.Net Wiki useful.

Go to the Main Page to see the Topic Outline.

Go to the Generalized Suggested Outline for information on case-specific details for each page.

Go to the Test Page for examples on how to use references in the page.


Relevant Article Depot:

NMBA NMBD


Standards/Guidelines

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

Neuromuscular blockade in children

Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study

Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care


Physiology

Development of the neuromuscular junction and neuromuscular blocking agents in neonates, infants and children: A narrative review

Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.

Pseudocholinesterase Deficiency

Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance



Monitoring

Neuromuscular block management: evidence-based principles and practice

Quantitative Neuromuscular Monitoring and Postoperative Outcomes: A Narrative Review

Neuromuscular Monitoring in the Perioperative Period

Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants

Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data

Intraoperative neuromuscular monitoring site and residual paralysis

Quantitative Neuromuscular Monitoring in Clinical Practice: A Professional Practice Change Initiative

Pediatric Intraoperative Electromyographic Responses at the Adductor Pollicis and Flexor Hallucis Brevis Muscles: A Prospective, Comparative Analysis

Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs

Skin Injury after Removal of Electrode Used for Quantitative Monitoring of Neuromuscular Transmission

Agents

Depolarizing


Succinylcholine

The place of suxamethonium in pediatric anesthesia

Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele


Non-Depolarizing


Rocuronium

Intramuscular rocuronium

Bioavailability of intramuscular rocuronium in infants and children

Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study

Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children

Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action

Test Your Knowledge: unique advantage of rocuronium


Vecuronium


Cis-atracurium


Antagonism/Reversal

Assessment of neuromuscular blockade in children at the time of block reversal and the removal of the endotracheal tube

A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade

Measuring Success of Patient Safety Initiatives: The 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade

A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis


Sugammadex

StatPearls: Sugammadex

Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children

Encapsulation dynamics of neuromuscular blocking drugs by sugammadex

Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults

The comparative efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. A Cochrane systematic review with meta-analysis and trial sequential analysis

Sugammadex for reversal of neuromuscular blockade in pediatric patients: Results from a phase IV randomized study

Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study

Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study

Advantages and pitfalls of clinical application of sugammadex

Cardiac arrest following sugammadex administration

Encapsulation Dynamics of Neuromuscular Blocking Drugs by Sugammadex

A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis

A retrospective observational cross-sectional study of intraoperative neuromuscular blocking agent choice and dosing in a US paediatric referral hospital before and after introduction of sugammadex

Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter

Recurarisation after sugammadex in children: review of case reports and recommendations

Factors Associated With Decision to Use and Dosing of Sugammadex in Children: A Retrospective Cross-Sectional Observational Study

Impact of Sugammadex Introduction on Using Neuromuscular Blockade and Endotracheal Intubation in a Pediatric Hospital: A Retrospective, Observational Cross-Sectional Study

X tweet about sugammadex

Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?

Heart rate changes following the administration of sugammadex in children: a prospective, observational study

Sugammadex for reversal of neuromuscular blockade in neonates and infants <2 years old: results from a phase IV randomized clinical trial

Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations

Retrospective analysis of the safety and efficacy of sugammadex versus neostigmine for the reversal of neuromuscular blockade in children

Current evidence for the use of sugammadex in children

Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age

Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal

A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis


Sugammadexand Women, Hormonal Regulation, and Contraceptives,

A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception

What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives

Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure


Neostigmine

Rocuronium-Sugammadex Versus Cisatracurium-Neostigmine in Kidney Disease: Making Sense of Surprising Results

Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring

Anaphylaxis

Sugammadex and rocuronium-induced anaphylaxis

Sugammadex in the management of rocuronium-induced anaphylaxis

Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports

The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?

Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study

Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort

Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity

Incidence of immediate hypersensitivity to sugammadex in Aotearoa New Zealand: a retrospective cohort study


Historic

Gallamine


Micacurium

Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury


Curare