Neuromuscular Blockade: Difference between revisions
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<b>Standards/Guidelines</b> | <b>Standards/Guidelines</b> | ||
[https://pubmed.ncbi.nlm.nih.gov/36520073/ 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade | [https://pubmed.ncbi.nlm.nih.gov/36520073/ 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade] | ||
[https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children] | [https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children] | ||
[https://pubmed.ncbi.nlm.nih.gov/30594097/ Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study] | [https://pubmed.ncbi.nlm.nih.gov/30594097/ Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study] | ||
[https://pubmed.ncbi.nlm.nih.gov/36377554/ Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care] | |||
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[https://link.springer.com/article/10.2165/00003088-200443020-00001 Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance] | [https://link.springer.com/article/10.2165/00003088-200443020-00001 Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance] | ||
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[https://pubmed.ncbi.nlm.nih.gov/28795964/ Neuromuscular Monitoring in the Perioperative Period] | [https://pubmed.ncbi.nlm.nih.gov/28795964/ Neuromuscular Monitoring in the Perioperative Period] | ||
[https://pubmed.ncbi.nlm.nih.gov/6990835/ Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants] | |||
[https://pubmed.ncbi.nlm.nih.gov/31607388/ Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data] | [https://pubmed.ncbi.nlm.nih.gov/31607388/ Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data] | ||
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[https://pubs.asahq.org/anesthesiology/article/141/2/262/141383/Accuracy-and-Precision-of-Three-Acceleromyographs Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs] | [https://pubs.asahq.org/anesthesiology/article/141/2/262/141383/Accuracy-and-Precision-of-Three-Acceleromyographs Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs] | ||
[https://journals.lww.com/anesthesiology/fulltext/2025/08000/skin_injury_after_removal_of_electrode_used_for.26.aspx Skin Injury after Removal of Electrode Used for Quantitative Monitoring of Neuromuscular Transmission] | |||
<b>Agents</b> | <b>Agents</b> | ||
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[https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia] | [https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia] | ||
[https://pubmed.ncbi.nlm.nih.gov/3946815/ Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele] | |||
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[https://pubs.asahq.org/anesthesiology/article/139/1/A16/138250/Goldilocks-and-the-Three-Rocuronium-Reversals-A Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study] | [https://pubs.asahq.org/anesthesiology/article/139/1/A16/138250/Goldilocks-and-the-Three-Rocuronium-Reversals-A Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study] | ||
[https://pubmed.ncbi.nlm.nih.gov/12378667/ Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children] | |||
[https://pubmed.ncbi.nlm.nih.gov/10485771/ Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action] | |||
[[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium | [[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium | ||
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Sugammadex | Sugammadex | ||
[https://www.statpearls.com/ArticleLibrary/viewarticle/29661 StatPearls: Sugammadex] | |||
[https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children] | [https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children] | ||
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[https://www.bjaopen.org/article/S2772-6096(22)00091-0/fulltext Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study] | [https://www.bjaopen.org/article/S2772-6096(22)00091-0/fulltext Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study] | ||
[https://pubmed.ncbi.nlm.nih.gov/33329823/ Advantages and pitfalls of clinical application of sugammadex] | [https://pubmed.ncbi.nlm.nih.gov/33329823/ Advantages and pitfalls of clinical application of sugammadex] | ||
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[https://www.bjanaesthesia.org/article/S0007-0912(23)00548-2/fulltext Recurarisation after sugammadex in children: review of case reports and recommendations] | [https://www.bjanaesthesia.org/article/S0007-0912(23)00548-2/fulltext Recurarisation after sugammadex in children: review of case reports and recommendations] | ||
[https://journals.lww.com/anesthesia-analgesia/fulltext/2025/01000/factors_associated_with_decision_to_use_and_dosing.14.aspx Factors Associated With Decision to Use and Dosing of Sugammadex in Children: A Retrospective Cross-Sectional Observational Study] | |||
[https://pubmed.ncbi.nlm.nih.gov/39058621/ Impact of Sugammadex Introduction on Using Neuromuscular Blockade and Endotracheal Intubation in a Pediatric Hospital: A Retrospective, Observational Cross-Sectional Study] | |||
[https://x.com/apsforg/status/1898792243835883675?s=46&t=X_9iaGrsYZbY5PJKh6nAPQ X tweet about sugammadex] | |||
[https://pubmed.ncbi.nlm.nih.gov/39976619/ Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?] | |||
[https://pubmed.ncbi.nlm.nih.gov/31980926/ Heart rate changes following the administration of sugammadex in children: a prospective, observational study] | |||
[https:// | [https://journals.lww.com/anesthesiology/abstract/9900/sugammadex_for_reversal_of_neuromuscular_blockade.682.aspx Sugammadex for reversal of neuromuscular blockade in neonates and infants <2 years old: results from a phase IV randomized clinical trial] | ||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/32324657/ Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations] | ||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective analysis of the safety and efficacy of sugammadex versus neostigmine for the reversal of neuromuscular blockade in children] | ||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/27859917/ Current evidence for the use of sugammadex in children] | ||
[https:// | [https://pubmed.ncbi.nlm.nih.gov/37792601/ Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age] | ||
[https://pubmed.ncbi.nlm.nih.gov/37279102/ Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal] | |||
[https://pubmed.ncbi.nlm.nih.gov/37027807/ A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis] | |||
Sugammadexand Women, Hormonal Regulation, and Contraceptives, | |||
[https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15902 A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception] | |||
[https:// | [https://anesth-pain-med.org/m/journal/view.php?doi=10.17085/apm.23041 What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives] | ||
[https://www.apsf.org/article/safety-of-sugammadex-in-pregnancy-pediatrics-and-renal-failure/ Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure] | |||
Neostigmine | |||
[https:// | [https://journals.lww.com/anesthesia-analgesia/fulltext/2025/05000/rocuronium_sugammadex_versus.1.aspx Rocuronium-Sugammadex Versus Cisatracurium-Neostigmine in Kidney Disease: Making Sense of Surprising Results] | ||
[https://pubmed.ncbi.nlm.nih.gov/37171989/ Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring] | |||
'''Anaphylaxis''' | |||
[https://pubmed.ncbi.nlm.nih.gov/26646837/ Sugammadex and rocuronium-induced anaphylaxis] | |||
[https://pubmed.ncbi.nlm.nih.gov/21149287/ Sugammadex in the management of rocuronium-induced anaphylaxis] | |||
[https://pubmed.ncbi.nlm.nih.gov/35212434/ Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports] | |||
[https://pubmed.ncbi.nlm.nih.gov/22512555/ The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?] | |||
[https://www.bjanaesthesia.org/article/S0007-0912(23)00104-6/fulltext Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study] | |||
[https://www.bjanaesthesia.org/article/S0007-0912(24)00560-9/fulltext Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort] | [https://www.bjanaesthesia.org/article/S0007-0912(24)00560-9/fulltext Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort] | ||
[https://www.bjanaesthesia.org/article/S0007-0912(24)00716-5/fulltext Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity] | [https://www.bjanaesthesia.org/article/S0007-0912(24)00716-5/fulltext Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity] | ||
[https:// | [https://www.bjanaesthesia.org/article/S0007-0912(25)00284-3/fulltext Incidence of immediate hypersensitivity to sugammadex in Aotearoa New Zealand: a retrospective cohort study] | ||
<b>Historic</b> | |||
Gallamine | |||
Micacurium | |||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/10638896/ Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury] | ||
Curare | |||
Revision as of 22:52, 25 September 2025
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Relevant Article Depot:
NMBA NMBD
Standards/Guidelines
Neuromuscular blockade in children
Physiology
Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.
Pseudocholinesterase Deficiency
Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance
Monitoring
Neuromuscular block management: evidence-based principles and practice
Quantitative Neuromuscular Monitoring and Postoperative Outcomes: A Narrative Review
Neuromuscular Monitoring in the Perioperative Period
Intraoperative neuromuscular monitoring site and residual paralysis
Agents
Depolarizing
Succinylcholine
The place of suxamethonium in pediatric anesthesia
Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele
Non-Depolarizing
Rocuronium
Bioavailability of intramuscular rocuronium in infants and children
Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study
Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children
Test Your Knowledge: unique advantage of rocuronium
Vecuronium
Cis-atracurium
Antagonism/Reversal
Sugammadex
Encapsulation dynamics of neuromuscular blocking drugs by sugammadex
Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults
Advantages and pitfalls of clinical application of sugammadex
Cardiac arrest following sugammadex administration
Encapsulation Dynamics of Neuromuscular Blocking Drugs by Sugammadex
Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter
Recurarisation after sugammadex in children: review of case reports and recommendations
Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?
Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations
Current evidence for the use of sugammadex in children
Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal
Sugammadexand Women, Hormonal Regulation, and Contraceptives,
Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure
Neostigmine
Anaphylaxis
Sugammadex and rocuronium-induced anaphylaxis
Sugammadex in the management of rocuronium-induced anaphylaxis
Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort
Historic
Gallamine
Micacurium
Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury
Curare