Neuromuscular Blockade: Difference between revisions
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NMBA | NMBA | ||
NMBD | NMBD | ||
<b>Standards/Guidelines</b> | <b>Standards/Guidelines</b> | ||
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[https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children] | [https://pubmed.ncbi.nlm.nih.gov/10983014/ Neuromuscular blockade in children] | ||
[https://pubmed.ncbi.nlm.nih.gov/30594097/ Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study] | |||
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[https://pubmed.ncbi.nlm.nih.gov/7114542/ Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.] | [https://pubmed.ncbi.nlm.nih.gov/7114542/ Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.] | ||
[[Pseudocholinesterase Deficiency]] | |||
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[https://www.bjaed.org/article/S2058-5349(23)00143-9/fulltext Neuromuscular block management: evidence-based principles and practice] | [https://www.bjaed.org/article/S2058-5349(23)00143-9/fulltext Neuromuscular block management: evidence-based principles and practice] | ||
[https://pubmed.ncbi.nlm.nih.gov/34813652/ Quantitative Neuromuscular Monitoring and Postoperative Outcomes: A Narrative Review] | |||
[https://pubmed.ncbi.nlm.nih.gov/28795964/ Neuromuscular Monitoring in the Perioperative Period] | |||
[https://pubmed.ncbi.nlm.nih.gov/31607388/ Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data] | |||
[https://pubmed.ncbi.nlm.nih.gov/23001053/ Intraoperative neuromuscular monitoring site and residual paralysis] | |||
[https://pubmed.ncbi.nlm.nih.gov/35188958/ Quantitative Neuromuscular Monitoring in Clinical Practice: A Professional Practice Change Initiative] | |||
<b>Agents</b> | <b>Agents</b> | ||
Depolarizing | ''Depolarizing'' | ||
Succinylcholine | |||
[https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia] | [https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9592.2009.03032.x The place of suxamethonium in pediatric anesthesia] | ||
Non-Depolarizing | |||
:: | ''Non-Depolarizing'' | ||
Rocuronium | |||
[https://pubmed.ncbi.nlm.nih.gov/9054273/][[TYK6 |Intramuscular rocuronium]] | |||
[https://pubmed.ncbi.nlm.nih.gov/9366462/][[TYK6 |Bioavailability of intramuscular rocuronium in infants and children]] | |||
[[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium | [[TYK6 |Test Your Knowledge]]: unique advantage of rocuronium | ||
Vecuronium | |||
Cis-atracurium | |||
<b>Antagonism/Reversal</b> | |||
: | [https://pubmed.ncbi.nlm.nih.gov/21474022/ Assessment of neuromuscular blockade in children at the time of block reversal and the removal of the endotracheal tube] | ||
[https://pubmed.ncbi.nlm.nih.gov/33543867/ A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade] | |||
[https://pubmed.ncbi.nlm.nih.gov/36520074/ Measuring Success of Patient Safety Initiatives: The 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade] | |||
[https://pubs.asahq.org/anesthesiology/article/139/1/6/138070/A-Dose-finding-Study-of-Sugammadex-for-Reversal-of A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis] | |||
Sugammadex | |||
[https://pubmed.ncbi.nlm.nih.gov/31584918/ Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children] | |||
[https://pubs.asahq.org/anesthesiology/article/doi/10.1097/ALN.0000000000004442/137334/Encapsulation-dynamics-of-neuromuscular-blocking Encapsulation dynamics of neuromuscular blocking drugs by sugammadex] | |||
[https://pubmed.ncbi.nlm.nih.gov/28806470/ Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults] | |||
[https://pubmed.ncbi.nlm.nih.gov/29280475/ The comparative efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. A Cochrane systematic review with meta-analysis and trial sequential analysis] | |||
[https://pubmed.ncbi.nlm.nih.gov/34878707/ Sugammadex for reversal of neuromuscular blockade in pediatric patients: Results from a phase IV randomized study] | |||
[https://www.bjanaesthesia.org/article/S0007-0912(19)30835-9/fulltext Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study] | |||
[https://www.bjaopen.org/article/S2772-6096(22)00091-0/fulltext Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study] | |||
[https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15902 A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception] | |||
[https://pubmed.ncbi.nlm.nih.gov/33329823/ Advantages and pitfalls of clinical application of sugammadex] | |||
[https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1002/anr3.12233 Cardiac arrest following sugammadex administration] | |||
[https://pubs.asahq.org/anesthesiology/article/138/2/152/137334/Encapsulation-Dynamics-of-Neuromuscular-Blocking Encapsulation Dynamics of Neuromuscular Blocking Drugs by Sugammadex] | |||
[https://pubs.asahq.org/anesthesiology/article/139/1/6/138070/A-Dose-finding-Study-of-Sugammadex-for-Reversal-of A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis] | |||
[https://www.bjanaesthesia.org/article/S0007-0912(23)00385-9/fulltext A retrospective observational cross-sectional study of intraoperative neuromuscular blocking agent choice and dosing in a US paediatric referral hospital before and after introduction of sugammadex] | |||
[https://pubs.asahq.org/anesthesiology/article/139/1/108/138037/Sugammadex-Vial-Wastage-Implications-for-the-Cost Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter] | |||
Neostigmine | |||
'''Anaphylaxis''' | |||
[https://pubmed.ncbi.nlm.nih.gov/26646837/ Sugammadex and rocuronium-induced anaphylaxis] | |||
[https://pubmed.ncbi.nlm.nih.gov/21149287/ Sugammadex in the management of rocuronium-induced anaphylaxis] | |||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/35212434/ Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports] | ||
[https://pubmed.ncbi.nlm.nih.gov/ | [https://pubmed.ncbi.nlm.nih.gov/22512555/ The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?] | ||
[https:// | [https://www.bjanaesthesia.org/article/S0007-0912(23)00104-6/fulltext Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study] | ||
<b>Historic</b> | |||
Gallamine | |||
Micacurium | |||
[https://pubmed.ncbi.nlm.nih.gov/10638896/ Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury] | [https://pubmed.ncbi.nlm.nih.gov/10638896/ Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury] | ||
Curare | |||
[https://pubmed.ncbi.nlm.nih.gov/10485771/ https://pubmed.ncbi.nlm.nih.gov/10485771/] | [https://pubmed.ncbi.nlm.nih.gov/10485771/ https://pubmed.ncbi.nlm.nih.gov/10485771/] | ||
Suárez Delgado JM, Hernández Soto R, Vilches Martín MJ, Romero RR, Vaz Calderón MA, García Perla JL. Anaesthetic considerations for myelomeningocele in neonates. Paediatr Anaesth. 1998; 8(4): 363-4. PMID: 9672939 | Suárez Delgado JM, Hernández Soto R, Vilches Martín MJ, Romero RR, Vaz Calderón MA, García Perla JL. Anaesthetic considerations for myelomeningocele in neonates. Paediatr Anaesth. 1998; 8(4): 363-4. PMID: 9672939 | ||
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Dierdorf SF, McNiece WL, Rao CC, Wolfe TM, Means LJ. Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele. Anesthesiology. 1986 Feb; 64(2): 272-3. PMID: 3946815 | Dierdorf SF, McNiece WL, Rao CC, Wolfe TM, Means LJ. Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele. Anesthesiology. 1986 Feb; 64(2): 272-3. PMID: 3946815 | ||
Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age. Paediatr Anaesth. 2023 Oct 4. doi: 10.1111/pan.14773. Epub ahead of print. PMID: 37792601 | Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age. Paediatr Anaesth. 2023 Oct 4. doi: 10.1111/pan.14773. Epub ahead of print. PMID: 37792601 | ||
Revision as of 22:21, 25 September 2025
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Relevant Article Depot:
NMBA NMBD
Standards/Guidelines
Neuromuscular blockade in children
Physiology
Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.
Pseudocholinesterase Deficiency
Monitoring
Neuromuscular block management: evidence-based principles and practice
Quantitative Neuromuscular Monitoring and Postoperative Outcomes: A Narrative Review
Neuromuscular Monitoring in the Perioperative Period
Intraoperative neuromuscular monitoring site and residual paralysis
Agents
Depolarizing
Succinylcholine
The place of suxamethonium in pediatric anesthesia
Non-Depolarizing
Rocuronium
[2]Bioavailability of intramuscular rocuronium in infants and children
Test Your Knowledge: unique advantage of rocuronium
Vecuronium
Cis-atracurium
Antagonism/Reversal
Sugammadex
Encapsulation dynamics of neuromuscular blocking drugs by sugammadex
Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults
Advantages and pitfalls of clinical application of sugammadex
Cardiac arrest following sugammadex administration
Encapsulation Dynamics of Neuromuscular Blocking Drugs by Sugammadex
Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter
Neostigmine
Anaphylaxis
Sugammadex and rocuronium-induced anaphylaxis
Sugammadex in the management of rocuronium-induced anaphylaxis
Historic
Gallamine
Micacurium
Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury
Curare
https://pubmed.ncbi.nlm.nih.gov/10485771/
Suárez Delgado JM, Hernández Soto R, Vilches Martín MJ, Romero RR, Vaz Calderón MA, García Perla JL. Anaesthetic considerations for myelomeningocele in neonates. Paediatr Anaesth. 1998; 8(4): 363-4. PMID: 9672939
Dierdorf SF, McNiece WL, Rao CC, Wolfe TM, Means LJ. Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele. Anesthesiology. 1986 Feb; 64(2): 272-3. PMID: 3946815
Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age. Paediatr Anaesth. 2023 Oct 4. doi: 10.1111/pan.14773. Epub ahead of print. PMID: 37792601
Recurarisation after sugammadex in children: review of case reports and recommendations
Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance
Thilen SR, Sherpa JR, James AM, Cain KC, Treggiari MM, Bhananker SM. Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring. Anesth Analg. 2024 Sep 1;139(3):536-544. doi: 10.1213/ANE.0000000000006511. Epub 2023 May 12. PMID: 37171989.
Mason LJ, Betts EK. Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants. Anesthesiology. 1980 May;52(5):441-2. doi: 10.1097/00000542-198005000-00015. PMID: 6990835.
Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study
Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort
Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children
Safety of Sugammadex in Pregnancy, Pediatrics, and Renal Failure
Unintended Consequences: Is Sugammadex Changing the Way We Deliver Anesthesia?
Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium
[Grigg E. Sugammadex and neuromuscular reversal: Special focus on neonatal and infant populations. Curr Opin Anaesthesiol. 2020 Jun; 33(3): 374-380. PMID: 32324657
Gaver RS, Brenn BR, Gartley A, Donahue BS. Retrospective analysis of the safety and efficacy of sugammadex versus neostigmine for the reversal of neuromuscular blockade in children. Anesth Analg. 2019 Oct; 129(4): 1124-1129. PMID: 31584918
Tobias JD. Current evidence for the use of sugammadex in children. Paediatr Anaesth. 2017 Feb; 27(2): 118-125. PMID: 27859917
Todd MM, Kopman AF: Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal. Anesthesiology 2023, 139(1):1–3.
Thilen SR, Weigel WA, Todd MM, Dutton RP, Lien CA, Grant SA, Szokol JW, Eriksson LI, Yaster M, Grant MD et al: 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology 2023, 138(1):13–41.
Fuchs-Buder T, Romero CS, Lewald H, Lamperti M, Afshari A, Hristovska AM, Schmartz D, Hinkelbein J, Longrois D, Popp M et al: Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care. European journal of anaesthesiology 2023, 40(2):82–94.
Bowdle TA, Haththotuwegama KJ, Jelacic S, Nguyen ST, Togashi K, Michaelsen KE: A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis. Anesthesiology 2023, 139(1):6–15.