Local Anesthetics in Children

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Basic pharmacology of local anaesthetics

Local anaesthetic dosage of peripheral nerve blocks in children: analysis of 40 121 blocks from the Pediatric Regional Anesthesia Network database

Baby-Blocks: Local Anesthetic Dosing

Comparative Methods to Predict Redosing of Bupivacaine and Ropivacaine in Truncal Catheters

Supplemental Table S1. Clinically reported bupivacaine redosing

Supplemental Table S2. Clinically reported ropivacaine redosing

Supplemental Table S3. Bupivacaine peripheral/neuraxial pharmacokinetic elimination

Supplemental Table S4. Bupivacaine intravenous pharmacokinetic elimination

Supplemental Table S5. Ropivacaine peripheral/neuraxial pharmacokinetic elimination

Supplemental Table S6. Ropivacaine intravenous pharmacokinetic elimination

Supplemental Figure S1. Elimination half-life without adjuvants

Detection of intravascular injection of regional anaesthetics in children

Fisher QA, Shaffner DH, Yaster M. Detection of intravascular injection of regional anaesthetics in children [see comments]. CanJAnaesth. 1997 1997;44(6):592-598. Not in File.

Alpha-1-acid glycoprotein and its potential impact on local anesthetic dose in neonates

Essentials of local anesthetic pharmacology

Lidocaine Infusions for Pain Management in Pediatrics

The European Society of Regional Anaesthesia and Pain Therapy/American Society of Regional Anesthesia and Pain Medicine Recommendations on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia

Linnarsson C, Bartocci M, Larsson BA, Eksborg S, von Horn H, Olofsson MA. Alpha-1-acid glycoprotein and its potential impact on local anesthetic dose in neonates. Pediatric Anesthesia. 2023;33(7):571-576. doi:https://doi.org/10.1111/pan.14672

Lerman J, Strong HA, LeDez KM, Swartz J, Rieder MJ, Burrows FA. Effects of age on the serum concentration of alpha 1-acid glycoprotein and the binding of lidocaine in pediatric patients. ClinPharmacolTher. 1989 1989;46(2):219-225. Not in File.

Plasma concentrations of alpha-1-acid glycoprotein in preterm and term newborns: influence of mode of delivery and implications for plasma protein binding of local anaesthetics

Chloroprocaine for epidural anesthesia in infants and children

Fundamentals and innovations in regional anaesthesia for infants and children

Habib AS, Gadsden J, Carvalho B. Liposomal Bupivacaine for Abdominal Fascial Plane Blocks: No Evidence or Lack of Relevant Evidence? Anesthesiology. 2024 May 1;140(5):871-873. doi: 10.1097/ALN.0000000000004933. PMID: 38592357.

Hussain N, Speer J, Abdallah FW. Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials. Anesthesiology. 2024 May 1;140(5):906-919. doi: 10.1097/ALN.0000000000004932. PMID: 38592360.

Society for Pediatric Anesthesia Annual Meeting Lecture: Liposomal bupivacaine in children: what do we know?

Free academic discourse and the law: the case of liposomal bupivacaine

Liposomal bupivacaine - Defining efficacy, how effective is effective?

Local anesthetic dosing and toxicity of pediatric truncal catheters: a narrative review of published practice

ATOTW 533: Perioperative Lignocaine

Topical use of local anesthetics

Efficacy of Emla (Eutectic Mixture of Local Anaesthetics) and Let (Lidocaine, Epinephrine, Tetracaine) for Topical Use in Wound Management for Children: A Systematic Review and Meta-Analysis

The use of EMLA cream to decrease venipuncture pain in children

A comparative study of 10% lidocaine spray versus eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA) to attenuate pain of peripheral venous cannulation in children: A prospective randomized control trial at a tertiary care centre

Test Your Knowledge:POTENCY of local anesthetics

Test Your Knowledge:treatment guidelines for local anesthetic toxicity