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The unique advantage of rocuronium over other intermediate duration non-depolarizing muscle relaxants (NDMR) is which of the following? | The unique advantage of rocuronium over other intermediate duration non-depolarizing muscle relaxants (NDMR) is which of the following? | ||
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E. Lack of potentiation with aminoglycoside antibiotics | E. Lack of potentiation with aminoglycoside antibiotics | ||
<div class="mw-customtoggle-TYK_Answer" style="text-align: right; color:#0000ff">Click for Answer</div> | |||
<div class="mw-collapsible- | <div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-TYK_Answer"> | ||
==Answer== | ==Answer== | ||
The answer is C. The first two letters of the name rocuronium stands for '''rapid onset'''. Of the intermediate duration nondepolarizing muscle relaxants, it has the most rapid onset of action at clinical dosages. Rocuronium has a similar duration of action to vecuronium, | The answer is C. The first two letters of the name rocuronium stands for '''rapid onset'''. Of the intermediate duration nondepolarizing muscle relaxants, it has the most rapid onset of action at clinical dosages. Rocuronium has a similar duration of action to vecuronium, | ||
atracurium, and cisatracurium. At an ED95 dose (0.3 mg/kg), the onset time is 1.5 to 3 minutes, whereas with | atracurium, and cisatracurium. At an ED95 dose (0.3 mg/kg), the onset time is 1.5 to 3 minutes, whereas with | ||
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[http://www.drugbank.ca/drugs/DB00728 Rocuronium (DrugBank)] | [http://www.drugbank.ca/drugs/DB00728 Rocuronium (DrugBank)] | ||
==Keywords== | ==Keywords== | ||
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Latest revision as of 23:14, 22 January 2022
The unique advantage of rocuronium over other intermediate duration non-depolarizing muscle relaxants (NDMR) is which of the following?
A. Ultra short duration of action
B. Metabolism by plasma pseudocholinesterase
C. More rapid onset of action
D. Lack of need for reversal
E. Lack of potentiation with aminoglycoside antibiotics
Answer
The answer is C. The first two letters of the name rocuronium stands for rapid onset. Of the intermediate duration nondepolarizing muscle relaxants, it has the most rapid onset of action at clinical dosages. Rocuronium has a similar duration of action to vecuronium, atracurium, and cisatracurium. At an ED95 dose (0.3 mg/kg), the onset time is 1.5 to 3 minutes, whereas with the other intermediate nondepolarizing muscle relaxants, the onset time is 3 to 7 minutes. At larger doses (i.e., 2xED95 or 0.6 mg/kg), onset time can be reduced to 1 to 1.5 minutes
Notes
Lambertus van den Broek, MD∗, MD J.Mar K.H. Wierda, PhD, †, Nicky J. Smeulers, MD‡, Gert Jan van Santen§, Monique G.L. Leclercq§, MD Pim J. Hennis, PhD‖ Clinical pharmacology of rocuronium (ORG 9426): Study of the time course of action, dose requirement, reversibility, and pharmacokinetics Journal of Clinical Anesthesia Volume 6, Issue 4, July–August 1994, Pages 288–296