Neuromuscular Blockade

This is a Stub Notice. This page has not been completed. You can work on this page by signing in and going to the Edit tab. Thanks for helping to make PedsAnesthesia.Net Wiki useful.

Go to the Main Page to see the Topic Outline.

Go to the Generalized Suggested Outline for information on case-specific details for each page.

Go to the Test Page for examples on how to use references in the page.

Relevant Article Depot:

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology 2023;138:13-41

Neuromuscular block management: evidence-based principles and practice

Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.

Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children

Encapsulation dynamics of neuromuscular blocking drugs by sugammadex

Sugammadex for reversal of neuromuscular blockade in pediatric patients: Results from a phase IV randomized study

Neuromuscular blockade in children

Test Your Knowledge: unique advantage of rocuronium

Assessment of neuromuscular blockade in children at the time of block reversal and the removal of the endotracheal tube

Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study

A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade

Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults

The comparative efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. A Cochrane systematic review with meta-analysis and trial sequential analysis

Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study

Sugammadex and rocuronium-induced anaphylaxis

Safety of sugammadex for myasthaenia gravis patients undergoing general anaesthesia: a retrospective database study

A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception

Pseudocholinesterase Deficiency

Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury

A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade

Measuring Success of Patient Safety Initiatives: The 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade

Quantitative Neuromuscular Monitoring and Postoperative Outcomes: A Narrative Review

Neuromuscular Monitoring in the Perioperative Period

Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data

Intraoperative neuromuscular monitoring site and residual paralysis

Quantitative Neuromuscular Monitoring in Clinical Practice: A Professional Practice Change Initiative

Sugammadex and rocuronium-induced anaphylaxis

Advantages and pitfalls of clinical application of sugammadex

Cardiac arrest following sugammadex administration

Encapsulation Dynamics of Neuromuscular Blocking Drugs by Sugammadex

Intramuscular rocuronium

Bioavailability of intramuscular rocuronium in infants and children

https://pubmed.ncbi.nlm.nih.gov/10485771/

A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis

A retrospective observational cross-sectional study of intraoperative neuromuscular blocking agent choice and dosing in a US paediatric referral hospital before and after introduction of sugammadex

Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study

Suárez Delgado JM, Hernández Soto R, Vilches Martín MJ, Romero RR, Vaz Calderón MA, García Perla JL. Anaesthetic considerations for myelomeningocele in neonates. Paediatr Anaesth. 1998; 8(4): 363-4. PMID: 9672939

Dierdorf SF, McNiece WL, Rao CC, Wolfe TM, Means LJ. Failure of succinylcholine to alter plasma potassium in children with myelomeningocoele. Anesthesiology. 1986 Feb; 64(2): 272-3. PMID: 3946815

Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter

Sugammadex in the management of rocuronium-induced anaphylaxis

Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports

The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?

Analysis of the factors contributing to residual weakness after sugammadex administration in pediatric patients under 2 years of age. Paediatr Anaesth. 2023 Oct 4. doi: 10.1111/pan.14773. Epub ahead of print. PMID: 37792601

Recurarisation after sugammadex in children: review of case reports and recommendations

Antiepileptic-Induced Resistance to Neuromuscular Blockers: Mechanisms and Clinical Significance

Pediatric Intraoperative Electromyographic Responses at the Adductor Pollicis and Flexor Hallucis Brevis Muscles: A Prospective, Comparative Analysis

Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs

Thilen SR, Sherpa JR, James AM, Cain KC, Treggiari MM, Bhananker SM. Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring. Anesth Analg. 2024 Sep 1;139(3):536-544. doi: 10.1213/ANE.0000000000006511. Epub 2023 May 12. PMID: 37171989.

Mason LJ, Betts EK. Leg lift and maximum inspiratory force, clinical signs of neuromuscular blockade reversal in neonates and infants. Anesthesiology. 1980 May;52(5):441-2. doi: 10.1097/00000542-198005000-00015. PMID: 6990835.

Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study

Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort