TYK354

Which of the following is NOT a known complication of autologous hematopoietic stem cell transplantation?

a) Sinusoidal obstruction syndrome

b) Severe mucositis

c) Bronchiolitis obliterans

d) Graft versus host disease (GVHD)

e) All of the above are complications

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Answer

Answer d. Graft versus host disease is a function of an assault on the host by the donor immunologic system. As such, it only occurs following allogeneic transplants; in patients receiving autologous HSCT there is extremely low risk of GVHD (although the risk is not completely absent). Interesting, there is also a “graft-versus-tumor” effect, which explains the decreased malignancy recurrence rate following allogeneic as compared to autologous HSCT.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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