TYK197

Effective medications in the treatment of bradycardia in the denervated (transplanted) heart include:

a) Epinephrine

b) Ephedrine

c) Phenylephrine

d) β-blockade

e) Atropine

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Answer

Answer a.

The transplanted heart is denervated and lacks any efferent or afferent autonomic supply. Although it maintains normal contractility, it will require direct acting agents (such as epinephrine) for pharmacological manipulation. Indirect-acting medications including ephedrine and atropine will not be effective. Phenylephrine and β-blockade are likely to decrease heart rate and would not be helpful in this case.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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