TYK393

Rocuronium and vecuronium have a longer duration of action in neonates due to:

a) Larger volume of distribution

b) Smaller volume of distribution

c) There is no difference

d) Increased clearance

e) Decreased plasma esterase degradation

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Answer

Answer a. Both rocuronium and vecuronium have a longer duration of action in neonates due to a large volume of distribution and mildly decreased clearance. Rocuronium undergoes primarily hepatic elimination with some renal elimination and vecuronium undergoes hepatic metabolism and both renal and hepatic elimination.

Notes

This question originally printed in the Pediatric Anesthesiology Review Topics kindle book series, and appears courtesy of Naerthwyn Press, LLC.

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