Mitochondrial Disease

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Relevant Article Depot:

A review of anaesthetic outcomes in patients with genetically confirmed mitochondrial disorders

Mitochondrial Disease and Anesthesia

References:

Hsieh VC, Niezgoda J, Sedensky MM, Hoppel CL, Morgan PG. Anesthetic Hypersensitivity in a Case-Controlled Series of Patients With Mitochondrial Disease. Anesthesia and analgesia. Oct 1 2021;133(4):924-932. doi:10.1213/ane.0000000000005430

Parikh S, Goldstein A, Koenig MK, et al. Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society. Genet Med. Sep 2015;17(9):689-701. doi:10.1038/gim.2014.177

Niezgoda J, Morgan PG. Anesthetic considerations in patients with mitochondrial defects. Paediatric anaesthesia. Sep 2013;23(9):785-93. doi:10.1111/pan.12158

Ferrari M, Jain IH, Goldberger O, et al. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. May 23 2017;114(21):E4241-e4250. doi:10.1073/pnas.1621511114

Grange RMH, Sharma R, Shah H, et al. Hypoxia ameliorates brain hyperoxia and NAD(+) deficiency in a murine model of Leigh syndrome. Mol Genet Metab. May 2021;133(1):83-93. doi:10.1016/j.ymgme.2021.03.005

Jain IH, Zazzeron L, Goli R, et al. Hypoxia as a therapy for mitochondrial disease. Science. Apr 1 2016;352(6281):54-61. doi:10.1126/science.aad9642

Open Anesthesia: Anesthetic Considerations in Patients with Mitochondrial Disease