TYK41 - Revision history

WikiSysop at 22:26, 23 January 2022

2022-01-23T22:26:28Z

← Older revision		Revision as of 22:26, 23 January 2022
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	The storage of red blood cells (RBC) in the blood bank leads to a progressively lower oxygen carrying capacity over time. Once these RBC are transfused to a patient, how long does it take before normal oxygen carrying capacity is restored?		The storage of red blood cells (RBC) in the blood bank leads to a progressively lower oxygen carrying capacity over time. Once these RBC are transfused to a patient, how long does it take before normal oxygen carrying capacity is restored?

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	D. > 24 hours but < 48 hours after transfusion		D. > 24 hours but < 48 hours after transfusion

	E. > 48 hours after transfusion		E. > 48 hours after transfusion<div class="mw-customtoggle-TYK_Answer" style="text-align: right; color:#0000ff">Click for Answer</div>
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	==Answer==		==Answer==
	The correct answer is D. There are several things that occur with ex vivo storage of RBC's - collectively referred to as the "storage lesion." First, ATP is depleted and membrane lipids and cytoskeletal elements are damaged (oxidant injury) - this leads to decreased deformability of the red cell in the microcirculation (it gets "clogged up" in the capillaries). Second, the levels of 2,3-DPG are essentially depleted to zero after a week of storage. Fortunately, 2,3-DPG levels return to normal within 24 hours or so following transfusion. Hence, normal oxygen carrying capacity is back to normal somewhere between 24-48 hours after transfusion. Until that time, RBC are essentially a good volume expander, but you may not necessarily get all the oxygen delivery benefits!		The correct answer is D. There are several things that occur with ex vivo storage of RBC's - collectively referred to as the "storage lesion." First, ATP is depleted and membrane lipids and cytoskeletal elements are damaged (oxidant injury) - this leads to decreased deformability of the red cell in the microcirculation (it gets "clogged up" in the capillaries). Second, the levels of 2,3-DPG are essentially depleted to zero after a week of storage. Fortunately, 2,3-DPG levels return to normal within 24 hours or so following transfusion. Hence, normal oxygen carrying capacity is back to normal somewhere between 24-48 hours after transfusion. Until that time, RBC are essentially a good volume expander, but you may not necessarily get all the oxygen delivery benefits!


	==Notes==		==Notes==
	<references />		<references />


	==Keywords==		==Keywords==
	:


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WikiSysop: 1 revision imported

2021-03-20T16:48:29Z

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← Older revision	Revision as of 16:48, 20 March 2021
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https://pedsanesthesia.net/wikiOLD032021>DrBobGreenberg at 15:30, 1 December 2014

2014-12-01T15:30:22Z

New page

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The storage of red blood cells (RBC) in the blood bank leads to a progressively lower oxygen carrying capacity over time. Once these RBC are transfused to a patient, how long does it take before normal oxygen carrying capacity is restored?

A. < 6 hours after transfusion

B. > 6 hours but < 12 hours after transfusion

C. > 12 hours but < 24 hours after transfusion

D. > 24 hours but < 48 hours after transfusion

E. > 48 hours after transfusion

<div class="mw-collapsible-content">
==Answer==
The correct answer is D. There are several things that occur with ex vivo storage of RBC's - collectively referred to as the "storage lesion." First, ATP is depleted and membrane lipids and cytoskeletal elements are damaged (oxidant injury) - this leads to decreased deformability of the red cell in the microcirculation (it gets "clogged up" in the capillaries). Second, the levels of 2,3-DPG are essentially depleted to zero after a week of storage. Fortunately, 2,3-DPG levels return to normal within 24 hours or so following transfusion. Hence, normal oxygen carrying capacity is back to normal somewhere between 24-48 hours after transfusion. Until that time, RBC are essentially a good volume expander, but you may not necessarily get all the oxygen delivery benefits!

==Notes==
<references />

==Keywords==
:

</div>

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