TYK24 - Revision history

WikiSysop: /* Answer */

2022-01-22T23:18:41Z

Answer

← Older revision		Revision as of 23:18, 22 January 2022
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	==Answer==		==Answer==
	The answer is D. Fentanyl is more lipid soluble than morphine, so it passes across the blood-brain barrier more easily and has a more rapid onset of action. Fentanyl also has a larger volume of distribution (Vd), slower plasma clearance, and longer elimination half-life than morphine. However, the duration of action of fentanyl (when given in small bolus doses) is much shorter than that of morphine because fentanyl is rapidly redistributed from the brain to inactive tissue sites (e.g., lipid sites). In larger bolus doses or continuous infusions, these tissue sites can become saturated, and the pharmacologic action of fentanyl becomes considerably prolonged. This is known as context sensitive half life and why if the kid has been on a fentanyl infusion for a while, don't expect it to be gone an hour after you shut if off.		The answer is D. Fentanyl is more lipid soluble than morphine, so it passes across the blood-brain barrier more easily and has a more rapid onset of action. Fentanyl also has a larger volume of distribution (Vd), slower plasma clearance, and longer elimination half-life than morphine. However, the duration of action of fentanyl (when given in small bolus doses) is much shorter than that of morphine because fentanyl is rapidly redistributed from the brain to inactive tissue sites (e.g., lipid sites). In larger bolus doses or continuous infusions, these tissue sites can become saturated, and the pharmacologic action of fentanyl becomes considerably prolonged. This is known as context sensitive half life and why if the kid has been on a fentanyl infusion for a while, don't expect it to be gone an hour after you shut it off.

	==Notes==		==Notes==
	<references />		<references />

WikiSysop at 23:16, 22 January 2022

2022-01-22T23:16:41Z

← Older revision		Revision as of 23:16, 22 January 2022
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	The most important reason for the more rapid onset and shorter duration of action of fentanyl compared with		The most important reason for the more rapid onset and shorter duration of action of fentanyl compared with
	morphine is the difference in which of the following?		morphine is the difference in which of the following?
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	E. Protein binding		E. Protein binding
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	<div class="mw-collapsible-~~content~~">
	==Answer==		==Answer==

	The answer is D. Fentanyl is more lipid soluble than morphine, so it passes across the blood-brain barrier more easily and has a more rapid onset of action. Fentanyl also has a larger volume of distribution (Vd), slower plasma clearance, and longer elimination half-life than morphine. However, the duration of action of fentanyl (when given in small bolus doses) is much shorter than that of morphine because fentanyl is rapidly redistributed from the brain to inactive tissue sites (e.g., lipid sites). In larger bolus doses or continuous infusions, these tissue sites can become saturated, and the pharmacologic action of fentanyl becomes considerably prolonged. This is known as context sensitive half life and why if the kid has been on a fentanyl infusion for a while, don't expect it to be gone an hour after you shut if off.		The answer is D. Fentanyl is more lipid soluble than morphine, so it passes across the blood-brain barrier more easily and has a more rapid onset of action. Fentanyl also has a larger volume of distribution (Vd), slower plasma clearance, and longer elimination half-life than morphine. However, the duration of action of fentanyl (when given in small bolus doses) is much shorter than that of morphine because fentanyl is rapidly redistributed from the brain to inactive tissue sites (e.g., lipid sites). In larger bolus doses or continuous infusions, these tissue sites can become saturated, and the pharmacologic action of fentanyl becomes considerably prolonged. This is known as context sensitive half life and why if the kid has been on a fentanyl infusion for a while, don't expect it to be gone an hour after you shut if off.

	==Notes==		==Notes==
	<references />		<references />
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	==Keywords==		==Keywords==
	:


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WikiSysop: 1 revision imported

2021-03-05T02:34:44Z

1 revision imported

← Older revision	Revision as of 02:34, 5 March 2021
(No difference)

metawikimedia>JustinHamrick at 02:28, 3 March 2015

2015-03-03T02:28:36Z

New page

__NOTOC__
<div class="mw-collapsible mw-collapsed" style="width:100%">
The most important reason for the more rapid onset and shorter duration of action of fentanyl compared with
morphine is the difference in which of the following?

A. Volume of distribution

B. Hepatic clearance

C. Renal clearance

D. Lipid solubility

E. Protein binding

<div class="mw-collapsible-content">
==Answer==

The answer is D. Fentanyl is more lipid soluble than morphine, so it passes across the blood-brain barrier more easily and has a more rapid onset of action. Fentanyl also has a larger volume of distribution (Vd), slower plasma clearance, and longer elimination half-life than morphine. However, the duration of action of fentanyl (when given in small bolus doses) is much shorter than that of morphine because fentanyl is rapidly redistributed from the brain to inactive tissue sites (e.g., lipid sites). In larger bolus doses or continuous infusions, these tissue sites can become saturated, and the pharmacologic action of fentanyl becomes considerably prolonged. This is known as context sensitive half life and why if the kid has been on a fentanyl infusion for a while, don't expect it to be gone an hour after you shut if off.

==Notes==
<references />
[http://www.frca.co.uk/article.aspx?articleid=100946 Anaesthesia UK:Pharmacology of Opioids II]

==Keywords==
:

</div>

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