TYK22 - Revision history

WikiSysop at 23:12, 22 January 2022

2022-01-22T23:12:11Z

← Older revision		Revision as of 23:12, 22 January 2022
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	Which of the following is NOT true concerning clonidine?		Which of the following is NOT true concerning clonidine?

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	D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE)		D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE)
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	==Answer==		==Answer==

	The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated.		The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated.


	==Notes==		==Notes==
	<references />		<references />
			:[[wikipedia:Clonidine]]

	==Keywords==		==Keywords==
	~~:[[wikipedia:Clonidine]]~~

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WikiSysop: 1 revision imported

2021-03-05T02:34:41Z

1 revision imported

← Older revision	Revision as of 02:34, 5 March 2021
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metawikimedia>JustinHamrick at 13:13, 16 February 2015

2015-02-16T13:13:59Z

New page

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Which of the following is NOT true concerning clonidine?

A. It is a central acting alpha-2 agonist working in the pontomedullary region of the CNS

B. The net-effect of its administration is a decrease in sympathetic nervous system activity

C. It can be used in the diagnosis of pheochromocytoma

D. Binding of clonidine to presynaptic alpha-2 agonist receptors decreases presynaptic sodium levels, and inhibits the release of norepinephrine (NE)

<div class="mw-collapsible-content">
==Answer==

The answer is D. Binding of the receptors will decrease presynaptic CALCIUM levels and decrease NE release. All of the others are true. Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for pheochromocytoma which is a catecholamine-synthesizing tumor, usually of the adrenal medulla. In a clonidine suppression test plasma catecholamines levels are measured before and 3 hours after a 0.3 µg/kg oral test dose has been given to a patient. A positive test occurs if there is no decrease in plasma levels. I.E., if a patient has a pheo, the levels of catecholamines (NE) will remain elevated.

==Notes==
<references />

==Keywords==
:[[wikipedia:Clonidine]]

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