Rubinstein-Taybi Syndrome - Revision history

WikiSysop at 14:35, 7 January 2025

2025-01-07T14:35:24Z

← Older revision		Revision as of 14:35, 7 January 2025
Line 7:		Line 7:


	~~Hennekam RC~~. Bibliography on Rubinstein Taybi syndrome~~. Am J Med Genet. 1990;6:77–83. doi: 10.1002/ajmg.1320370614.~~		[https://pubmed.ncbi.nlm.nih.gov/2118784/ Bibliography on Rubinstein-Taybi syndrome]

	* Cervical hyperkyphosis can be seen in 62% of patients with RTS, while scoliosis can be seen in 38%. Such vertebral anomalies may make it difficult to provide a suitable position during intubation and airway control in patients.		* Cervical hyperkyphosis can be seen in 62% of patients with RTS, while scoliosis can be seen in 38%. Such vertebral anomalies may make it difficult to provide a suitable position during intubation and airway control in patients.


	~~Park CH, Park KH, Choi BY~~. Management of Anesthesia for Rubinstein-Taybi syndrome~~. Korean J Anesthesiol. 2012;63:571–2. doi: 10.4097/kjae.2012.63.6.571.~~		[https://pubmed.ncbi.nlm.nih.gov/23277824/ Management of Anesthesia for Rubinstein-Taybi syndrome]

	* Another important feature of the syndrome that may affect the airway management is the risk of aspiration. Hereditary tracheal stenosis, abnormal pulmonary lobulation, excessive mucus secretion and gastroesophageal reflux increase the risk of aspiration in these patients.		* Another important feature of the syndrome that may affect the airway management is the risk of aspiration. Hereditary tracheal stenosis, abnormal pulmonary lobulation, excessive mucus secretion and gastroesophageal reflux increase the risk of aspiration in these patients.


	~~Loomba RS, Geddes G~~. Tricuspid atresia and pulmonary atresia in a child with Rubinstein-Taybi syndrome~~. Ann Pediatr Cardiol. 2015;8:157–60. doi: 10.4103/0974-2069.154151.~~		[https://pubmed.ncbi.nlm.nih.gov/26085772/ Tricuspid atresia and pulmonary atresia in a child with Rubinstein-Taybi syndrome]

	* Heart defects are present in 24–38% of patients with RTS. The large part of anomalies first identified in patients with RTS in 1964 consisted of isolated lesions, such as the atrium septum defect, ventricular septum defect, patent ductus arteriosus, coarctation of the aorta, pulmonary valve stenosis, bicuspid aorta, aortic valve stenosis, vascular rings and conduction abnormalities.		* Heart defects are present in 24–38% of patients with RTS. The large part of anomalies first identified in patients with RTS in 1964 consisted of isolated lesions, such as the atrium septum defect, ventricular septum defect, patent ductus arteriosus, coarctation of the aorta, pulmonary valve stenosis, bicuspid aorta, aortic valve stenosis, vascular rings and conduction abnormalities.
	* Because succinylcholine, neostigmine and atropine will increase the risk of arrhythmia, particularly in patients with heart defects, the use of a rocuronium–sugammadex combination may be a good alternative.		* Because succinylcholine, neostigmine and atropine will increase the risk of arrhythmia, particularly in patients with heart defects, the use of a rocuronium–sugammadex combination may be a good alternative.

WikiSysop at 14:32, 7 January 2025

2025-01-07T14:32:00Z

← Older revision		Revision as of 14:32, 7 January 2025
Line 2:		Line 2:


	~~Agarwal S, Ahmad YH, Talpesh M, Zestos M~~. Anesthetic management of children with Rubinstein-Taybi syndrome-case reports~~. Middle East J Anesthesiol. 2011;21:309–12.~~		[https://pubmed.ncbi.nlm.nih.gov/22435286/ Anesthetic management of children with Rubinstein-Taybi syndrome-case reports]

	* Patients with RTS are considered as a potential patient group with difficult intubation. Micrognatia, retrognathia, a broad nasal bridge, an abnormally large or ‘beak-shaped’ nose, a narrow high-arched palate, a hypoplastic maxilla and a small mouth opening are considered as the main craniofacial reasons for laryngoscopy; these factors cause intubation difficulty in this patient group.		* Patients with RTS are considered as a potential patient group with difficult intubation. Micrognatia, retrognathia, a broad nasal bridge, an abnormally large or ‘beak-shaped’ nose, a narrow high-arched palate, a hypoplastic maxilla and a small mouth opening are considered as the main craniofacial reasons for laryngoscopy; these factors cause intubation difficulty in this patient group.

WikiSysop: WikiSysop moved page Rubinstein-Taybi syndrome to Rubinstein-Taybi Syndrome without leaving a redirect

2025-01-06T23:01:06Z

WikiSysop moved page Rubinstein-Taybi syndrome to Rubinstein-Taybi Syndrome without leaving a redirect

← Older revision	Revision as of 23:01, 6 January 2025
(No difference)

WikiSysop: WikiSysop moved page Rubinstein-taybi syndrome to Rubinstein-Taybi syndrome without leaving a redirect

2025-01-06T23:00:21Z

WikiSysop moved page Rubinstein-taybi syndrome to Rubinstein-Taybi syndrome without leaving a redirect

← Older revision	Revision as of 23:00, 6 January 2025
(No difference)

Hbratto1: added citation

2025-01-06T22:48:43Z

added citation

← Older revision		Revision as of 22:48, 6 January 2025
Line 1:		Line 1:
			Information taken from: [https://pmc.ncbi.nlm.nih.gov/articles/PMC4925006/#b15-tard-44-3-152 Anaesthetic Management of Children with Rubinstein-Taybi Syndrome]


	Agarwal S, Ahmad YH, Talpesh M, Zestos M. Anesthetic management of children with Rubinstein-Taybi syndrome-case reports. Middle East J Anesthesiol. 2011;21:309–12.		Agarwal S, Ahmad YH, Talpesh M, Zestos M. Anesthetic management of children with Rubinstein-Taybi syndrome-case reports. Middle East J Anesthesiol. 2011;21:309–12.

	* Patients with RTS are considered as a potential patient group with difficult intubation. Micrognatia, retrognathia, a broad nasal bridge, an abnormally large or ‘beak-shaped’ nose, a narrow high-arched palate, a hypoplastic maxilla and a small mouth opening are considered as the main craniofacial reasons for laryngoscopy; these factors cause intubation difficulty in this patient group		* Patients with RTS are considered as a potential patient group with difficult intubation. Micrognatia, retrognathia, a broad nasal bridge, an abnormally large or ‘beak-shaped’ nose, a narrow high-arched palate, a hypoplastic maxilla and a small mouth opening are considered as the main craniofacial reasons for laryngoscopy; these factors cause intubation difficulty in this patient group.


	Hennekam RC. Bibliography on Rubinstein Taybi syndrome. Am J Med Genet. 1990;6:77–83. doi: 10.1002/ajmg.1320370614.		Hennekam RC. Bibliography on Rubinstein Taybi syndrome. Am J Med Genet. 1990;6:77–83. doi: 10.1002/ajmg.1320370614.

	* Cervical hyperkyphosis can be seen in 62% of patients with RTS, while scoliosis can be seen in 38%. Such vertebral anomalies may make it difficult to provide a suitable position during intubation and airway control in patients		* Cervical hyperkyphosis can be seen in 62% of patients with RTS, while scoliosis can be seen in 38%. Such vertebral anomalies may make it difficult to provide a suitable position during intubation and airway control in patients.

Hbratto1: Added new page about RTS, a rare genetic disorder.

2025-01-06T22:46:01Z

Added new page about RTS, a rare genetic disorder.

New page

Agarwal S, Ahmad YH, Talpesh M, Zestos M. Anesthetic management of children with Rubinstein-Taybi syndrome-case reports. Middle East J Anesthesiol. 2011;21:309–12.

* Patients with RTS are considered as a potential patient group with difficult intubation. Micrognatia, retrognathia, a broad nasal bridge, an abnormally large or ‘beak-shaped’ nose, a narrow high-arched palate, a hypoplastic maxilla and a small mouth opening are considered as the main craniofacial reasons for laryngoscopy; these factors cause intubation difficulty in this patient group

Hennekam RC. Bibliography on Rubinstein Taybi syndrome. Am J Med Genet. 1990;6:77–83. doi: 10.1002/ajmg.1320370614.

* Cervical hyperkyphosis can be seen in 62% of patients with RTS, while scoliosis can be seen in 38%. Such vertebral anomalies may make it difficult to provide a suitable position during intubation and airway control in patients

Park CH, Park KH, Choi BY. Management of Anesthesia for Rubinstein-Taybi syndrome. Korean J Anesthesiol. 2012;63:571–2. doi: 10.4097/kjae.2012.63.6.571.

* Another important feature of the syndrome that may affect the airway management is the risk of aspiration. Hereditary tracheal stenosis, abnormal pulmonary lobulation, excessive mucus secretion and gastroesophageal reflux increase the risk of aspiration in these patients.

Loomba RS, Geddes G. Tricuspid atresia and pulmonary atresia in a child with Rubinstein-Taybi syndrome. Ann Pediatr Cardiol. 2015;8:157–60. doi: 10.4103/0974-2069.154151.

* Heart defects are present in 24–38% of patients with RTS. The large part of anomalies first identified in patients with RTS in 1964 consisted of isolated lesions, such as the atrium septum defect, ventricular septum defect, patent ductus arteriosus, coarctation of the aorta, pulmonary valve stenosis, bicuspid aorta, aortic valve stenosis, vascular rings and conduction abnormalities.
* Because succinylcholine, neostigmine and atropine will increase the risk of arrhythmia, particularly in patients with heart defects, the use of a rocuronium–sugammadex combination may be a good alternative.